About: Efatutazone Dihydrochloride

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About: Efatutazone Dihydrochloride Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Efatutazone Dihydrochloride
rdfs:subClassOf	Differentiation Inducer nodeID://b655086 nodeID://b655087 nodeID://b655088
Has_Target	PPAR gamma
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Efatutazone Dihydrochloride
UMLS_CUI	C1721778
CAS_Registry	223132-38-5
FDA_UNII_Code	76B44WEA8O
Contributing_Source	FDA
PDQ_Open_Trial_Search_ID	529846
PDQ_Closed_Trial_Search_ID	529846
Chemical_Formula	C27H26N4O4S.2ClH
Legacy_Concept_Name	CS-7017
FULL_SYN	2,4-thiazolidinedione, 5-((4-((6-(4-amino-3,5-dimethylphenoxy)-1-methyl-1h-benzimidazol-2-yl)methoxy)phenyl)methyl)-, Hydrochloride (1:2)SNNCI Efatutazone DihydrochloridePTNCI Inolitazone DihydrochlorideSYNCI CS-7017CNNCI EFATUTAZONE DIHYDROCHLORIDEPTFDA76B44WEA8O
DEFINITION	The dihydrochloride salt of efatutazone, an orally bioavailable compound and an agonist of peroxisome proliferator-activated receptor gamma (PPAR-gamma) with potential antineoplastic activity. Efatutazone binds to and activates PPAR-gamma, a nuclear hormone receptor and a ligand-activated transcription factor controling gene expression involved in macromolecule metabolism and cell differentiation, specifically adipocyte differentiation. Mediated through activation of PPAR-gamma, this agent is capable of inducing cell differentiation and apoptosis, thereby leading to a reduction in cellular proliferation.NCI
code	C64764
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0498118

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