About: Methylprednisolone

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Attributes	Values
rdf:type	Class
rdfs:label	Methylprednisolone
rdfs:subClassOf	Therapeutic Glucocorticoid
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance Steroid
Preferred_Name	Methylprednisolone
NSC_Code	19987
UMLS_CUI	C0025815
CAS_Registry	83-43-2
Accepted_Therapeutic_Use_For	Adrenocortical insufficiency; Conditions requiring immunosuppression; Inflammatory conditions; Multiple Sclerosis; Nephrotic syndrome
In_Clinical_Trial_For	Acute lymphoblastic leukemia; Congenital bone marrow failure disorders; Connective tissue disease; Fanconi anemia; Hodgkins lymphoma; Leukemia; Lymphoma; Mucopolysaccharidosis I; Myelodysplastic and Myeloproliferative disease; Non-Hodgkins lymphoma; Post-transplant lymphoproliferative disorder
FDA_UNII_Code	X4W7ZR7023
Contributing_Source	FDA
ALT_DEFINITION	A corticosteroid hormone replacement.NCI-GLOSS
PDQ_Open_Trial_Search_ID	41528
PDQ_Closed_Trial_Search_ID	41528
Chemical_Formula	C22H30O5
Legacy_Concept_Name	Methylprednisolone
CHEBI_ID	CHEBI:6888
FULL_SYN	MethylprednisoloneSYDTPNSC0019987 Metilbetasone SolubileFBNCI DepMedaloneFBNCI SieropresolFBNCI Caberdelta MFBNCI Depo ModerinFBNCI Depo-NisoloneFBNCI methylprednisolonePTNCI-GLOSSCDR0000045370 MedrolSYDTPNSC0019987 MethylprednisolonePTDCP00191 6Alpha-MethylprednisoloneSNNCI Medrol VeridermFBNCI Veriderm MedrolFBNCI MedrateSYDTPNSC0019987 MedroneSYDTPNSC0019987 UrbasonSYDTPNSC0019987 WyacortSYDTPNSC0019987 Predni-M-TablinenFBNCI AdloneFBNCI MedrolBRNCI MethylprednisolonePTNCI RadilemFBNCI MedroneFBNCI UrbasonFBNCI WyacortFBNCI METHYLPREDNISOLONEPTFDAX4W7ZR7023 MethylprednisolonumSYNCI EmmetipiFBNCI DuraloneFBNCI Mega-StarFBNCI EsametoneFBNCI PrednilenFBNCI FirmacortFBNCI MeproloneBRNCI MetrocortBRNCI SummicortBRNCI MetysolonFBNCI Medlone 21BRNCI (6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dioneSNNCI SolpredoneFBNCI MetypresolFBNCI
DEFINITION	A synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone binds to and activates specific nuclear receptors, resulting in altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations.NCI
code	C647
sameAs	METHYLPREDNISOLONE METHYLPREDNISOLONE
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0013662
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