About: Pregabalin     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Pregabalin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Pregabalin
NSC_Code
  • 729898
UMLS_CUI
  • C0657912
CAS_Registry
  • 148553-50-8
In_Clinical_Trial_For
  • Glioblastoma multiforme; gliomas
FDA_UNII_Code
  • 55JG375S6M
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat nerve pain caused by diabetes or herpes zoster infection and certain types of seizures. It is being studied in the prevention and treatment of nerve pain in the hands and feet of cancer patients given chemotherapy. Pregabalin is a type of anticonvulsant.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 518288
PDQ_Closed_Trial_Search_ID
  • 518288
Chemical_Formula
  • C8H17NO2
Legacy_Concept_Name
  • Pregabalin
CHEBI_ID
  • CHEBI:64356
FULL_SYN
  • pregabalinPTNCI-GLOSSCDR0000537233
  • 3-Isobutyl GABASYNCI
  • LyricaPTNCI-GLOSSCDR0000559066
  • 3-(Aminomethyl)-5-methyl-hexanoic AcidSNNCI
  • LyricaBRNCI
  • CI 1008CNNCI
  • PREGABALINPTFDA55JG375S6M
  • PD 144723CNNCI
  • PregabalinPTNCI
DEFINITION
  • A 3-isobutyl derivative of gamma-amino butyric acid (GABA) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities. Although the exact mechanism of action is unknown, pregabalin selectively binds to alpha2delta (A2D) subunits of presynaptic voltage-dependent calcium channels (VDCCs) located in the central nervous system (CNS). Binding of pregabalin to VDCC A2D subunits prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons; synaptic transmission is inhibited and neuronal excitability is diminished. Pregabalin does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation.NCI
code
  • C64625
sameAs
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