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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Isavuconazole
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Isavuconazole
UMLS_CUI
  • C1832021
CAS_Registry
  • 241479-67-4
FDA_UNII_Code
  • 60UTO373KE
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 529357
PDQ_Closed_Trial_Search_ID
  • 529357
Chemical_Formula
  • C22H17F2N5OS
Legacy_Concept_Name
  • Isavuconazole
FULL_SYN
  • ISAVUCONAZOLEPTFDA60UTO373KE
  • IsavuconazolePTNCI
  • BAL8557CNNCI
DEFINITION
  • A water-soluble triazole prodrug with broad-spectrum antifungal activity. Isavuconazole is absorbed easily, given either orally or intravenously, and is hydrolyzed to its active moiety BAL4815 by plasma esterases. BAL4815 inhibits fungal cytochrome P450 lanosterol 14-alpha-demethylase (CYP51) that catalyzes the conversion of lanosterol to ergosterol, an important component of the fungal cell membrane. Enzyme inhibition by this agent leads to a decrease in ergosterol pool and therefore disturbs synthesis of fungal cell membrane, thereby increasing cell membrane permeability and promoting loss of essential intracellular elements. This ultimately causes fungal cell lysis and death.NCI
code
  • C64543
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