About: KSP Inhibitor AZD4877     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • KSP Inhibitor AZD4877
rdfs:subClassOf
Has_Target
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • KSP Inhibitor AZD4877
UMLS_CUI
  • C1879525
PDQ_Open_Trial_Search_ID
  • 522717
PDQ_Closed_Trial_Search_ID
  • 522717
Legacy_Concept_Name
  • AZD4877
FULL_SYN
  • AZD4877CNNCI
  • KSP Inhibitor AZD4877PTNCI
DEFINITION
  • A synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. AZD4877 selectively inhibits microtubule motor protein KSP (also called kinesin-5 or Eg5), which is essential for the formation of bipolar spindles and the proper segregation of sister chromatids during mitosis. Inhibition of KSP results in an inhibition of mitotic spindle assembly, activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, thereby causing cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neuronal transport, AZD4877 may be less likely to cause the peripheral neuropathy often associated with the tubulin-targeting agents.NCI
code
  • C64522
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