About: Oral Fludarabine Phosphate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Oral Fludarabine Phosphate
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • Oral Fludarabine Phosphate
UMLS_CUI
  • C1831839
PDQ_Open_Trial_Search_ID
  • 486428
PDQ_Closed_Trial_Search_ID
  • 486428
Legacy_Concept_Name
  • Oral_Fludarabine_Phosphate
FULL_SYN
  • Fludara OralBRNCI
  • Oral Fludarabine PhosphatePTNCI
DEFINITION
  • An oral formulation of the phosphate salt of fludarabine, a synthetic purine nucleoside analogue antimetabolite with antineoplastic activity. Fudarabine is preferentially transported into malignant cells and metabolized by deoxycytidine kinase to its active form, 2-fluoro-ara-ATP; 2-fluoro-ara-ATP competes directly with deoxyadenosine triphosphate (dATP) and inhibits alpha DNA polymerase, RNA reductase, and DNA primase, which may result in inhibition of DNA synthesis and cell death.NCI
code
  • C64338
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