About: Asparaginase Erwinia chrysanthemi     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Asparaginase Erwinia chrysanthemi
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Enzyme
  • Pharmacologic Substance
Preferred_Name
  • Asparaginase Erwinia chrysanthemi
NSC_Code
  • 106977
UMLS_CUI
  • C0771210
CAS_Registry
  • 9015-68-3
Accepted_Therapeutic_Use_For
  • Acute lymphocytic leukemia; Acute non-lymphocytic leukemia
FDA_UNII_Code
  • D733ET3F9O
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 601044
PDQ_Closed_Trial_Search_ID
  • 601044
Legacy_Concept_Name
  • Asparaginase-Erwinia
FULL_SYN
  • Asparaginase Erwinia chrysanthemiPTNCI
  • L-asparginase (Erwinia )SYNCI
  • CristantaspaseSYNCI
  • CrisantaspasumSYNCI
  • ASPARAGINASE ERWINIA CHRYSANTHEMIPTFDAD733ET3F9O
  • ErwinaseFBNCI
  • ErwinazeBRNCI
DEFINITION
  • An enzyme isolated from the bacterium Erwinia chrysanthemi (E. carotovora). Asparagine is critical to protein synthesis in leukemic cells, which cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting leukemic cells of asparagine and blocking protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle. This agent also induces apoptosis in tumor cells. The Erwinia-derived product is often used for those patients who have experienced a hypersensitivity reaction to the E. Coli formulation.NCI
code
  • C64260
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