About: Methadone Hydrochloride

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Attributes	Values
rdf:type	Class
rdfs:label	Methadone Hydrochloride
rdfs:subClassOf	Opioid Opioid Agonist nodeID://b692881 nodeID://b692882 nodeID://b692883 nodeID://b692884
Has_Free_Acid_Or_Base_Form	METHADONE
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Methadone Hydrochloride
NSC_Code	19600
UMLS_CUI	C0592779
CAS_Registry	1095-90-5
FDA_UNII_Code	229809935B
Contributing_Source	FDA
ALT_DEFINITION	A drug used to treat moderate to severe pain that does not respond to other types of pain medicine. It is also used to help people who are addicted to opioid drugs such as heroin. Methadone hydrochloride binds to opioid receptors in the central nervous system. It is a type of analgesic agent and a type of opioid.NCI-GLOSS A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. It also has a depressant action on the cough center and may be given to control intractable cough associated with terminal lung cancer. Methadone is also used as part of the treatment of dependence on opioid drugs, although prolonged use of methadone itself may result in dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)MSH2002_06_01
PDQ_Open_Trial_Search_ID	39498
PDQ_Closed_Trial_Search_ID	39498
Chemical_Formula	C21H27NO.HCl
Legacy_Concept_Name	Methadone
CHEBI_ID	CHEBI:50140
FULL_SYN	Methadone HydrochloridePTNCI METHADONE HYDROCHLORIDEPTFDA229809935B AlthoseSYDTPNSC0019600 AdanonBRNCI AlthoseBRNCI MethadoseBRNCI DolophineBRNCI methadone hydrochloridePTNCI-GLOSSCDR0000454762
DEFINITION	The hydrochloride salt of methadone, a synthetic opioid with analgesic activity. Similar to morphine and other morphine-like agents, methadone mimics the actions of endogenous peptides at CNS opioid receptors, primarily the mu-receptor, resulting in characteristic morphine-like effects including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia and physical dependence. Because of the prolonged half-life of methadone compared to other morphine-like agents such as heroin, the onset of opiate withdrawal symptoms is slower, the duration of opiate withdrawal is prolonged, and opiate withdrawal symptoms are less severe.NCI
code	C638
sameAs	Methadone Hydrochloride
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0474183
is Has_Salt_Form of	METHADONE
is sameAs of	Methadone Hydrochloride

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