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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Mofarotene
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Mofarotene
UMLS_CUI
  • C0247161
CAS_Registry
  • 125533-88-2
FDA_UNII_Code
  • 8K3CVY8F8V
Contributing_Source
  • FDA
Chemical_Formula
  • C29H39NO2
Legacy_Concept_Name
  • Mofarotene
FULL_SYN
  • MofaronteneSYNCI
  • MofarotenePTDCP08948
  • (E)-4-[2-[4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]phenoxy]ethyl]morpholineSNNCI
  • MOFAROTENEPTFDA8K3CVY8F8V
  • Ro 40-8757CNNCI
  • MofarotenePTNCI
DEFINITION
  • An arotinoic acid derivative with a morpholine structure in the polar end group with differentiation inducing and antineoplastic activity. Like other retinoic acid agents, mofarotene binds to and activates retinoic acid receptors (RARs), thereby altering the expression of certain genes leading to cell differentiation and decreased cell proliferation in susceptible cells. In addition, this agent is able to inhibit melanoma cell motility.NCI
code
  • C63667
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