About: Minocycline-EDTA     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Minocycline-EDTA
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Minocycline-EDTA
UMLS_CUI
  • C1831960
In_Clinical_Trial_For
  • Prevention of Catheter-Related Infections
ALT_DEFINITION
  • A substance being studied in the treatment of bacterial infections from catheters (flexible tubes used to deliver fluids into or take fluids from the body). It combines a drug used to treat infections with a drug that prevents blood clots. It is a type of tetracycline antibiotic.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 509172
PDQ_Closed_Trial_Search_ID
  • 509172
Legacy_Concept_Name
  • Minocycline-EDTA
FULL_SYN
  • M-EDTAPTNCI-GLOSSCDR0000546758
  • Minocycline-EDTAPTNCI
  • M-EDTAABNCI
  • Minocycline-EthylenediaminetetraacetateSYNCI
  • minocycline-EDTAPTNCI-GLOSSCDR0000528023
DEFINITION
  • A combination preparation containing minocycline, a broad-spectrum, semi-synthetic tetracycline antibiotic, and ethylenediaminetetraacetate (EDTA) with antimicrobial and anticoagulant activities. Minocycline exerts its bacteriostatic effect by binding to the bacterial 30S ribosomal subunit and preventing binding of aminoacyl-tRNA to the mRNA-ribosome complex during protein translation. This leads to an inhibition of bacterial protein synthesis and consequently interferes with cell growth. EDTA, a metal chelator, exerts its anticoagulant activity by binding to calcium, thereby impeding the activity of calcium-dependent coagulation proteins. This leads to an inhibition of thrombotic occlusion and prevention of bacterial colonization that could occur upon clot formation.NCI
code
  • C63545
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