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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Oral Ixabepilone
rdfs:subClassOf
Has_Target
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Oral Ixabepilone
NCI_META_CUI
  • CL415081
PDQ_Open_Trial_Search_ID
  • 486610
PDQ_Closed_Trial_Search_ID
  • 486610
Legacy_Concept_Name
  • Oral_Ixabepilone
FULL_SYN
  • Oral IxabepilonePTNCI
DEFINITION
  • An enteric-coated formulation of ixabepilone, a semisynthetic analogue of epothilone B and a non-taxane tubulin inhibitor, with antineoplastic activity. Ixabepilone binds to and stabilizes tubulin molecules, thereby interfering with the dynamics of microtubule assembly/disassembly. This results in cell cycle arrest at the G2-M phase and leads to apoptosis within fast growing tumor cells. This agent demonstrates antineoplastic activity against taxane-resistant cell lines. Compared to intravenously administered ixabepilone, the oral formulation provides a more manageable way to administer this agent.NCI
code
  • C63478
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