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AttributesValues
rdf:type
rdfs:label
  • Megestrol
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Steroid
Preferred_Name
  • Megestrol
UMLS_CUI
  • C0025175
CAS_Registry
  • 3562-63-8
Accepted_Therapeutic_Use_For
  • Anorexia; breast and endometrial carcinoma, palliative; cachexia
In_Clinical_Trial_For
  • Cachexia, cancer or chemotherapy-induced; hepatocellular carcinoma
FDA_UNII_Code
  • EA6LD1M70M
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to block estrogen and suppress the effects of estrogen and androgens. It is used to treat breast and endometrial cancer, and is being studied in the treatment of other types of cancer. It is also used to improve appetite in patients with cancer. Megestrol belongs to the group of hormones called progestins.NCI-GLOSS
Chemical_Formula
  • C22H30O3
Legacy_Concept_Name
  • Megestrol
CHEBI_ID
  • CHEBI:6722
FULL_SYN
  • Compound 5071SYNCI
  • MEGABNCI
  • Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-SNNCI
  • MEGESTROLPTFDAEA6LD1M70M
  • MegestrolPTNCI
  • megestrolPTNCI-GLOSSCDR0000046617
DEFINITION
  • A synthetic derivative of progesterone with antiestrogenic activity. Megestrol binds to and activates nuclear receptors which subsequently bind to and activate target genes for transcription. As an antiestrogen, this agent may inhibit the growth-stimulating effects of estrogen on estrogen-sensitive tumor cells. In addition, megestrol stimulates appetite in cachectic subjects.NCI
code
  • C630
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