About: LMP2A-Specific Cytotoxic T-Lymphocytes     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • LMP2A-Specific Cytotoxic T-Lymphocytes
rdfs:subClassOf
Semantic_Type
  • Cell
  • Pharmacologic Substance
Preferred_Name
  • LMP2A-Specific Cytotoxic T-Lymphocytes
UMLS_CUI
  • C1328049
PDQ_Open_Trial_Search_ID
  • 334454
PDQ_Closed_Trial_Search_ID
  • 334454
Legacy_Concept_Name
  • LMP2A-Specific_Cytotoxic_T_Lymphocytes
FULL_SYN
  • EBV-Specific Cytotoxic T-LymphocytesSYNCI
  • LMP2A-Specific Cytotoxic T-LymphocytesPTNCI
  • LMP2A-Specific CTLABNCI
DEFINITION
  • A preparation of cytotoxic T-lymphocytes (CTL), specifically reactive to Epstein-Barr virus (EBV) latent membrane protein-2A (LMP2A), with potential antineoplastic activity. T-lymphocytes are exposed ex vivo to dendritic cells (DCs) transfected with a replication-deficient adenovirus encoding EBV LMP2A. Subsequently, LMP2A-specific CTLs are exposed to EBV infected cells transfected with adenovirus encoding LMP2A, thereby further stimulating CTLs. Administered to patients with EBV-positive tumors, LMP2A-specific CTLs target LMP2A-positive cells, resulting in cell lysis and inhibition of cancer cell proliferation. EBV LMP2A may be expressed in various malignancies, including nasopharyngeal carcinoma and Hodgkin and non-Hodgkin lymphomas.NCI
code
  • C62784
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