About: Nintedanib

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Nintedanib
rdfs:subClassOf	Angiogenesis Inhibitor Tyrosine Kinase Inhibitor nodeID://b648722 nodeID://b648723 nodeID://b648724 nodeID://b648725
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Nintedanib
UMLS_CUI	C1879771
CAS_Registry	656247-17-5
FDA_UNII_Code	G6HRD2P839
Contributing_Source	FDA
ALT_DEFINITION	A substance being studied in the treatment of some types of cancer. BIBF 1120 blocks enzymes needed for cells to grow, and may prevent the growth of new blood vessels that tumors need to grow. It is a type of tyrosine kinase inhibitor and a type of antiangiogenesis agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID	504524
PDQ_Closed_Trial_Search_ID	504524
Chemical_Formula	C31H33N5O4
Legacy_Concept_Name	BIBF_1120
FULL_SYN	Methyl (3Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylidene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylateSNNCI tyrosine kinase inhibitor BIBF 1120PTNCI-GLOSSCDR0000546734 Multitargeted Tyrosine Kinase Inhibitor BIBF 1120SYNCI NINTEDANIBPTFDAG6HRD2P839 BIBF 1120PTNCI-GLOSSCDR0000524232 VargatefBRNCI BIBF 1120CNNCI BIBF-1120CNNCI IntedanibSYNCI NintedanibPTNCI
DEFINITION	An orally bioavailable, indolinone-derived, receptor tyrosine kinase (RTK) inhibitor with potential antiangiogenic and antineoplastic activities. Multitargeted tyrosine kinase inhibitor BIBF 1120 selectively binds to and inhibits vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet-derived growth factor receptor (PDGFR) tyrosine kinases, which may result in the induction of endothelial cell apoptosis; a reduction in tumor vasculature; and the inhibition of tumor cell proliferation and migration. In addition, this agent also inhibits members of the Src family of tyrosine kinases, including Src, Lck, Lyn, and FLT-3 (fms-like tyrosine kinase 3). VEGFR, FGFR and PDGFR RTKs play key roles in tumor angiogenesis.NCI
code	C62765
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0523861

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