About: CHP-HER-2 Peptide Vaccine

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Attributes	Values
rdf:type	Class
rdfs:label	CHP-HER-2 Peptide Vaccine
rdfs:subClassOf	Peptide Vaccine nodeID://b654307 nodeID://b654308 nodeID://b654309 nodeID://b654310
Semantic_Type	Pharmacologic Substance Immunologic Factor
Preferred_Name	CHP-HER-2 Peptide Vaccine
UMLS_CUI	C1831880
PDQ_Open_Trial_Search_ID	489124
PDQ_Closed_Trial_Search_ID	489124
Legacy_Concept_Name	CHP-HER-2_Peptide_Vaccine
FULL_SYN	CHP-HER-2 Peptide VaccinePTNCI Cholesterol-Bearing Hydrophobized Pullulan HER2 Protein 146SYNCI
DEFINITION	A peptide vaccine, containing nanoparticles of cholesteryl hydrophobized pullulan (CHP) complexed with the tumor-associated antigen HER-2/neu (ErbB-2), with potential antineoplastic activity. Her-2/neu, a member of the epidermal growth factor receptor (EGFR) family of tyrosine kinases, is overexpressed in various tumors, including breast, ovarian, and gastric cancers. Vaccination with CHP-HER-2 peptide vaccine may stimulate the host immune system to mount a humoral as well as a cytotoxic T-cell response against tumor cells expressing the HER-2/neu antigen. This results in an inhibition of tumor cell proliferation and tumor cell death. The self-aggregating CHP, composed of a pullulan backbone and cholesterol branches, forms stable colloidal nanoparticles in water.NCI
code	C62597

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