About: Recombinant Parathyroid Hormone     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Recombinant Parathyroid Hormone
rdfs:subClassOf
Has_Target
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Recombinant Parathyroid Hormone
UMLS_CUI
  • C1882913
CAS_Registry
  • 9002-64-6
FDA_UNII_Code
  • N19A0T0E5J
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 489119
PDQ_Closed_Trial_Search_ID
  • 489119
Legacy_Concept_Name
  • Recombinant_Parathyroid_Hormone
FULL_SYN
  • PARATHYROID HORMONEPTFDAN19A0T0E5J
  • Recombinant Parathyroid HormonePTNCI
DEFINITION
  • A recombinant therapeutic agent that is identical or similar to an 84-amino-acid polypeptide produced by the parathyroid gland which functions to maintain a constant concentration of calcium ions (Ca2+) in the extracellular fluid. In target tissues, parathyroid hormone (PTH) binds to and activates the PTH receptor (PTHR), a cell surface G protein-coupled receptor; there are two types of receptors, PTHR1 found in bone and the kidney and PTHR2 found primarily in the central nervous system (CNS), pancreas, testis, and placenta. Activation of PTHRs results in the activation of adenylyl cyclase and phospholipase C in target tissue cells, which, depending upon the specific target tissue, results in the enhancement of intestinal Ca2+ absorption, mobilization of bone Ca2+, and renal Ca2+ reabsorption.NCI
code
  • C62555
is rdfs:subClassOf of
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