About: Adenovirus Encoding Rat HER-2/neu     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Adenovirus Encoding Rat HER-2/neu
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Adenovirus Encoding Rat HER-2/neu
UMLS_CUI
  • C1831867
PDQ_Open_Trial_Search_ID
  • 488459
PDQ_Closed_Trial_Search_ID
  • 488459
Legacy_Concept_Name
  • Adenovirus_Encoding_Rat_Her-2_neu
FULL_SYN
  • Adenovirus Encoding Rat HER-2/neuPTNCI
DEFINITION
  • A replication-defective oncolytic adenovirus, encoding rat Her-2/neu (ErbB-2), with potential antineoplastic activity. Upon administration, adenovirus encoding rat HER-2/neu may induce an immune response against tumor cells expressing the HER-2/neu antigen, which may result in the immune-mediated inhibition of tumor cell proliferation and tumor cell death. Her-2/neu, a tumor-associated antigen and member of the epidermal growth factor receptor (EGFR) family of tyrosine kinases, is overexpressed in various tumor cell types.NCI
code
  • C62527
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