About: Bis(choline)tetrathiomolybdate

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Bis(choline)tetrathiomolybdate
rdfs:subClassOf	Angiogenesis Inhibitor Enzyme Inhibitor nodeID://b643359
Has_Target	Superoxide Dismutase [Cu-Zn]
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Bis(choline)tetrathiomolybdate
UMLS_CUI	C1831930
CAS_Registry	649749-10-0
FDA_UNII_Code	FD57A79R4P
Contributing_Source	FDA
ALT_DEFINITION	A substance being studied in the treatment of cancer. It may prevent the growth of new blood vessels that tumors need to grow. ATN-224 also blocks enzymes that cells need to divide and grow, and it may kill cancer cells. It is a type of antiangiogenesis agent and a type of superoxide dismutase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID	500040
PDQ_Closed_Trial_Search_ID	500040
Chemical_Formula	2C5H14NO.MoS4
Legacy_Concept_Name	ATN-224
FULL_SYN	BIS(CHOLINE)TETRATHIOMOLYBDATEPTFDAFD57A79R4P ATN-224PTNCI-GLOSSCDR0000633062 SOD1 inhibitor ATN-224PTNCI-GLOSSCDR0000633063 ATN-224CNNCI Bis(choline)tetrathiomolybdatePTNCI Ethanaminium, 2-Hydroxy-N,N,N-Trimethyl-, (T-4)-Tetrathioxomolybdate(2-) (2:1)SNNCI SOD1 Inhibitor ATN-224SYNCI
DEFINITION	An orally active second generation tetrathiomolybdate analog with anti-angiogenic and antineoplastic activities. ATN-224 selectively chelates the copper ion in superoxide dismutase 1 (SOD1) in endothelial cells, thereby depleting SOD1 of copper and inhibiting its activity. Inhibition of SOD1 interferes with the activation of several signal transduction pathways required for cellular proliferation and angiogenesis, including those mediated by ERK1/2 and FAK and Src kinases. This results in an inhibition of cell proliferation and angiogenesis as well as induction of apoptosis.NCI
code	C62514

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