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AttributesValues
rdf:type
rdfs:label
  • Denenicokin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Denenicokin
UMLS_CUI
  • C1831593
CAS_Registry
  • 716840-32-3
FDA_UNII_Code
  • A4LY1V9F0H
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 409696
PDQ_Closed_Trial_Search_ID
  • 409696
Legacy_Concept_Name
  • Recombinant_Human_Interleukin-21
FULL_SYN
  • L-methionyl(Human Interleukin-21)SYNCI
  • DenenicokinPTNCI
  • IL-21ABNCI
  • rIL-21ABNCI
  • rhIL-21ABNCI
  • DENENICOKINPTFDAA4LY1V9F0H
  • Recombinant Human Interleukin-21SYNCI
DEFINITION
  • A recombinant peptide similar to or identical to endogenous human cytokine interleukin-21 (IL-21) with potential antineoplastic activity. Denenicokin binds to and activates IL-21 receptors, expressed on T-cells, B-cells, dendritic cells (DC), and natural killer (NK) cells, modulating the proliferation and/or differentiation of T and B cells, promoting T cell survival, and increasing the cytolytic activity of cytotoxic T lymphocytes (CTLs) and NK cells.NCI
code
  • C62492
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