About: Amatuximab

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Amatuximab
rdfs:subClassOf	Antibodies, Monoclonal nodeID://b646249 nodeID://b646250 nodeID://b646251 nodeID://b646252
Has_Target	Mesothelin
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Amino Acid, Peptide, or Protein Immunologic Factor
Preferred_Name	Amatuximab
UMLS_CUI	C1831891
CAS_Registry	931402-35-6
FDA_UNII_Code	6HP0354G04
Contributing_Source	FDA
ALT_DEFINITION	A monoclonal antibody being studied in the treatment of some types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. Anti-mesothelin monoclonal antibody MORAb-009 binds to mesothelin (a protein that is made by some cancer cells) and stops the cells from dividing.NCI-GLOSS
PDQ_Open_Trial_Search_ID	489384
PDQ_Closed_Trial_Search_ID	489384
Chemical_Formula	C6394H9870N1694O2024S46
Legacy_Concept_Name	Anti-Mesothelin_Monoclonal_Antibody
FULL_SYN	Anti-Mesothelin Monoclonal Antibody MORAb-009SYNCI anti-mesothelin monoclonal antibody MORAb-009PTNCI-GLOSSCDR0000543500 Immunoglobulin G1, Anti-(mesothelin) (Human-Mouse Monoclonal MORAb-009 Heavy Chain), Disulfide with Human-Mouse Monoclonal MORAb-009 Kappa-Chain, DimerSYNCI AMATUXIMABPTFDA6HP0354G04 MORAb-009PTNCI-GLOSSCDR0000527374 MORAb-009CNNCI AmatuximabPTNCI
DEFINITION	A chimeric IgG1 monoclonal antibody against human mesothelin with potential anti-tumor activity. Amatuximab specifically targets mesothelin, a cell surface glycoprotein involved in cell adhesion and overexpressed on many epithelial-derived cancer cells. Upon binding to the mesothelin antigen, amatuximab triggers an antibody dependent cellular cytotoxicity (ADCC)-mediated host immune response against mesothelin-expressing cells, resulting in cell lysis.NCI
code	C62483
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0518005

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