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AttributesValues
rdf:type
rdfs:label
  • Tigatuzumab
rdfs:subClassOf
Has_Target
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • Tigatuzumab
UMLS_CUI
  • C2973415
PDQ_Open_Trial_Search_ID
  • 489323
PDQ_Closed_Trial_Search_ID
  • 489323
Legacy_Concept_Name
  • CS-1008
FULL_SYN
  • TigatuzumabPTNCI
  • Anti-DR5 MoAbSYNCI
  • anti-[Homo sapiens TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily Member 10B, DR5, TRAIL-R2, CD262)] Humanized Monoclonal TRA-8SYNCI
  • Anti-TRAIL-R2 MoAbSYNCI
  • CS-1008CNNCI
DEFINITION
  • A humanized agonistic monoclonal antibody directed against human tumor necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) with potential antitumor activity. Mimicking the natural receptor ligand TRAIL, tigatuzumab binds to TRAIL-R2, activating signal transduction pathways that may result in tumor cell apoptosis and a reduction in tumor growth. A member of the tumor necrosis factor (TNF) receptor family, TRAIL-R2, also known as DR5 (death receptor 5), is expressed on the surfaces of many types of malignant cells.NCI
code
  • C62482
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