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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Tamoxifen
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Tamoxifen
UMLS_CUI
  • C0039286
CAS_Registry
  • 10540-29-1
FDA_UNII_Code
  • 094ZI81Y45
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat certain types of breast cancer in women and men. It is also used to prevent breast cancer in women who have had ductal carcinoma in situ (abnormal cells in the ducts of the breast) and in women who are at a high risk of developing breast cancer. Tamoxifen is also being studied in the treatment of other types of cancer. It blocks the effects of the hormone estrogen in the breast. Tamoxifen is a type of antiestrogen.NCI-GLOSS
Chemical_Formula
  • C26H29NO
Legacy_Concept_Name
  • Tamoxifen_Base
CHEBI_ID
  • CHEBI:41774
FULL_SYN
  • TamoxifenPTDCP00273
  • 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-eneSNNCI
  • TAMOXIFENPTFDA094ZI81Y45
  • TamoxifenSYDTPNSC0180973
  • TamoxifenPTNCI
  • tamoxifenPTNCI-GLOSSCDR0000045576
DEFINITION
  • An antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth.NCI
code
  • C62078
sameAs
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