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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Ritodrine
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Ritodrine
UMLS_CUI
  • C0035661
CAS_Registry
  • 26652-09-5
FDA_UNII_Code
  • I0Q6O6740J
Contributing_Source
  • FDA
Chemical_Formula
  • C17H21NO3
Legacy_Concept_Name
  • Ritodrine
FULL_SYN
  • RITODRINEPTFDAI0Q6O6740J
  • RitodrinePTNCI
DEFINITION
  • A phenethylamine derivative with tocolytic activity. Ritodrine binds to and activates beta-2 adrenergic receptors of myometrial cells in the uterus, which decreases the intensity and frequency of uterine contractions. Specifically, ritodrine probably activates adenyl cyclase, thereby increasing production of cyclic adenosine monophosphate (cAMP), which in turn enhances the efflux of calcium from vascular smooth muscle cells. A lack of intracellular calcium prevents uterine myometrial contractions. In addition, this agent may directly inactivate myosin light chain kinase, a critical enzyme necessary for the initiation of muscle contractions.NCI
code
  • C61929
sameAs
http://linked.open...y/mesh/hasConcept
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