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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Lorazepam
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Lorazepam
NSC_Code
  • 289758
UMLS_CUI
  • C0699194
CAS_Registry
  • 846-49-1
FDA_UNII_Code
  • O26FZP769L
Contributing_Source
  • FDA
ALT_DEFINITION
  • An anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.MSH2002_06_01
  • A drug that is used to treat anxiety and certain seizure disorders (such as epilepsy), and to prevent nausea and vomiting caused by chemotherapy. It belongs to the families of drugs called antiemetics and benzodiazepines.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 39757
PDQ_Closed_Trial_Search_ID
  • 39757
Chemical_Formula
  • C15H10Cl2N2O2
Legacy_Concept_Name
  • Lorazepam
FULL_SYN
  • AtivanSYDTPNSC0289758
  • 7-Chloro-5-(2-chlorophenyl)-1, 3-Dihydro-3-Hydroxy-1,4- Benzodiazepin-2-oneSNNCI
  • LORAZEPAMPTFDAO26FZP769L
  • AtivanBRNCI
  • LorazepamPTNCI
  • lorazepamPTNCI-GLOSSCDR0000467846
DEFINITION
  • A benzodiazepine with anxiolytic, anti-anxiety, anticonvulsant, anti-emetic and sedative properties. Lorazepam enhances the effect of the inhibitory neurotransmitter gamma-aminobutyric acid on the GABA receptors by binding to a site that is distinct from the GABA binding site in the central nervous system. This leads to an increase in chloride channel opening events, a facilitation of chloride ion conductance, membrane hyperpolarization, and eventually inhibition of the transmission of nerve signals, thereby decreasing nervous excitation.NCI
code
  • C619
sameAs
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