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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Midodrine
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Midodrine
UMLS_CUI
  • C0026078
CAS_Registry
  • 42794-76-3
FDA_UNII_Code
  • 6YE7PBM15H
Contributing_Source
  • FDA
Chemical_Formula
  • C12H18N2O4
Legacy_Concept_Name
  • Midodrine
CHEBI_ID
  • CHEBI:6933
FULL_SYN
  • MIDODRINEPTFDA6YE7PBM15H
  • MidodrinePTNCI
DEFINITION
  • A direct-acting prodrug and sympathomimetic agent with antihypotensive properties. Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to an elevation of blood pressure. Desglymidodrine diffuses poorly across the blood-brain barrier, and is therefore not associated with effects on the central nervous system (CNS).NCI
code
  • C61846
sameAs
http://linked.open...y/mesh/hasConcept
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