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AttributesValues
rdf:type
rdfs:label
  • Mercaptopurine Anhydrous
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Mercaptopurine Anhydrous
UMLS_CUI
  • C1881785
CAS_Registry
  • 50-44-2
FDA_UNII_Code
  • PKK6MUZ20G
Contributing_Source
  • FDA
Chemical_Formula
  • C5H4N4S
Legacy_Concept_Name
  • Mercaptopurine_Anhydrous
CHEBI_ID
  • CHEBI:2208
  • CHEBI:50667
FULL_SYN
  • Mercaptopurine AnhydrousPTNCI
  • MERCAPTOPURINE ANHYDROUSPTFDAPKK6MUZ20G
DEFINITION
  • The anhydrous form of mercaptopurine, a thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities. Produced through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), mercaptopurine metabolites 6-thioguanosine-5'-phosphate (6-thioGMP) and 6-thioinosine monophosphate (T-IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the formation of purine nucleotides and inhibiting DNA synthesis. This agent is also incorporated into DNA in the form of deoxythioguanosine, which results in the disruption of DNA replication. In addition, mercaptopurine is converted to 6-methylmercaptopurine ribonucleoside (MMPR) by 6-thiopurine methyltransferase; MMPRs are also potent inhibitors of de novo purine synthesis.NCI
code
  • C61832
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