About: Lithium Citrate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Lithium Citrate
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Lithium Citrate
UMLS_CUI
  • C0125997
CAS_Registry
  • 6080-58-6
FDA_UNII_Code
  • 5Z6E9K79YV
Contributing_Source
  • FDA
Chemical_Formula
  • C6H5O7.3Li.4H2O
Legacy_Concept_Name
  • Lithium_Citrate
CHEBI_ID
  • CHEBI:64754
FULL_SYN
  • LITHIUM CITRATEPTFDA5Z6E9K79YV
  • Lithium CitratePTNCI
DEFINITION
  • The citrate salt of lithium, a monovalent cation with antimanic activity. Although the exact mechanism is unclear, lithium might exert its mood-stabilizing effect via reduction of catecholamine concentration mediated through transneuronal membrane transport of sodium ion by sodium-potassium-stimulated adenosine triphosphatase (Na-K-ATPase). Alternatively, lithium may decrease cyclic adenosine monophosphate (cAMP) concentrations, which would desensitize hormonal-sensitive adenylyl cyclase receptors. Furthermore, lithium, in recommended dosage, blocks the activity of inositol-1-phosphatase, thereby resulting in the subsequent decrease of postsynaptic second messengers, diacylglycerol and inositol triphosphate, that contribute to chronic cell stimulation by altering electrical activity in the neuron.NCI
code
  • C61812
sameAs
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