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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Halobetasol
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Halobetasol
UMLS_CUI
  • C0082787
CAS_Registry
  • 98651-66-2
FDA_UNII_Code
  • 9P6159HM7T
Contributing_Source
  • FDA
Chemical_Formula
  • C22H27ClF2O4
Legacy_Concept_Name
  • Halobetasol
FULL_SYN
  • HalobetasolPTNCI
  • HALOBETASOLPTFDA9P6159HM7T
DEFINITION
  • A synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictor activities. Halobetasol, a topical steroid, diffuses across cell membranes to interact with cytoplasmic corticosteroid receptors located in both the dermal and intradermal cells, thereby activating gene expression of anti-inflammatory proteins mediated via the corticosteroid receptor response element. Specifically, this agent induces phospholipase A2 inhibitory proteins, which inhibit the release of arachidonic acid, thereby inhibiting the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes. As a result, halobetasol reduces edema, erythema, and pruritus through its cutaneous effects on vascular dilation and permeability.NCI
code
  • C61781
sameAs
http://linked.open...y/mesh/hasConcept
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