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AttributesValues
rdf:type
rdfs:label
  • Fentanyl Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Fentanyl Hydrochloride
UMLS_CUI
  • C1714006
CAS_Registry
  • 1443-54-5
FDA_UNII_Code
  • 59H156XY46
Contributing_Source
  • FDA
Chemical_Formula
  • C22H28N2O.HCl
Legacy_Concept_Name
  • Fentanyl_Hydrochloride
FULL_SYN
  • Fentanyl HydrochloridePTNCI
  • FENTANYL HYDROCHLORIDEPTFDA59H156XY46
  • IonsysBRNCI
DEFINITION
  • The hydrochloride salt form of fentanyl, a synthetic, lipophilic phenylpiperidine opioid agonist with analgesic and anesthetic properties. Fentanyl selectively binds to the mu-receptor in the central nervous system (CNS) thereby mimicking the effects of endogenous opiates. Stimulation of the mu-subtype opioid receptor stimulates the exchange of GTP for GDP on the G-protein complex and subsequently inhibits adenylate cyclase. This results in a decrease in intracellular cAMP and leads to a reduction in the release of neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline. The analgesic effect of fentanyl is likely due to its metabolite morphine, which induces opening of G-protein-coupled inwardly rectifying potassium (GIRK) channels and blocks the opening of N-type voltage-gated calcium channels, thereby resulting in hyperpolarization and reduced neuronal excitability.NCI
code
  • C61762
is Has_Salt_Form of
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