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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Fenoldopam
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Fenoldopam
UMLS_CUI
  • C0060180
CAS_Registry
  • 67227-56-9
FDA_UNII_Code
  • INU8H2KAWG
Contributing_Source
  • FDA
Chemical_Formula
  • C16H16ClNO3
Legacy_Concept_Name
  • Fenoldopam
CHEBI_ID
  • CHEBI:5002
FULL_SYN
  • FENOLDOPAMPTFDAINU8H2KAWG
  • FenoldopamPTNCI
DEFINITION
  • A benzazepine derivative with vasodilatory and antihypertensive properties. Fenoldopam, a dopamine (DA) receptor agonist, binds specifically to peripheral DA1 receptors and to alpha-2 adrenoceptors with moderate affinity. However, this agent exhibits no significant affinity to DA2, other alpha adrenergic, beta adrenergic, muscarinic, or serotonergic receptors. Receptor binding modulates the transmembrane flux of ions, thereby stimulating adenylate cyclase activity, as well as the release of prolactin. This results in vasodilatation, increased renal blood flow thereby enhancing natriuresis and diuresis leading to a lowering in diastolic blood pressure.NCI
code
  • C61759
sameAs
http://linked.open...y/mesh/hasConcept
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