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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Ertapenem Sodium
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Ertapenem Sodium
UMLS_CUI
  • C1170745
CAS_Registry
  • 153832-38-3
FDA_UNII_Code
  • 2T90KE67L0
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 573502
PDQ_Closed_Trial_Search_ID
  • 573502
Chemical_Formula
  • C22H23N3O7S."H".Na
Legacy_Concept_Name
  • Ertapenem_Sodium
CHEBI_ID
  • CHEBI:60070
FULL_SYN
  • ERTAPENEM SODIUMPTFDA2T90KE67L0
  • Ertapenem SodiumPTNCI
  • InvanzBRNCI
DEFINITION
  • The sodium salt of ertapenem, a 1-beta-methyl carbapenem and a broad-spectrum beta-lactam antibiotic with bactericidal activity. Ertapenem binds to penicillin binding proteins (PBPs) located on the bacterial cell wall, in particular PBPs 2 and 3, thereby inhibiting the final transpeptidation step in the synthesis of peptidoglycan, an essential component of the bacterial cell wall. Inhibition of peptidoglycan synthesis results in weakening and lysis of the cell wall and cell death. In vitro, this agent has shown activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. Erapenem is resistant to hydrolysis by a variety of beta-lactamases, including penicillinases, cephalosporinases and extended-spectrum beta-lactamases.NCI
code
  • C61753
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
is sameAs of
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