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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Enclomiphene Citrate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Enclomiphene Citrate
UMLS_CUI
  • C0086214
CAS_Registry
  • 7599-79-3
FDA_UNII_Code
  • J303A6U9Y6
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 39307
PDQ_Closed_Trial_Search_ID
  • 39307
Chemical_Formula
  • C26H28ClNO.C6H8O7
Legacy_Concept_Name
  • Enclomiphene_Citrate
FULL_SYN
  • ENCLOMIPHENE CITRATEPTFDAJ303A6U9Y6
  • Enclomiphene CitratePTNCI
DEFINITION
  • The orally bioavailable citrate salt of enclomiphene, the trans-isomer of the nonsteroidal triphenylethylene compound clomiphene, with tissue-selective estrogenic and antiestrogenic activities. As a selective estrogen receptor modulator (SERM), enclomiphene binds to hypothalamic estrogen receptors, blocking the negative feedback of endogenous estrogens and stimulating the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus; released GnRH subsequently stimulates the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary, resulting in ovulation. In addition, this agent may bind to estrogen receptors on breast cancer cells, resulting in the inhibition of estrogen-stimulated proliferation in susceptible cell populations.NCI
code
  • C61745
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