About: Diflorasone     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Diflorasone
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Diflorasone
UMLS_CUI
  • C0304612
CAS_Registry
  • 2557-49-5
FDA_UNII_Code
  • T2DHJ9645W
Contributing_Source
  • FDA
Chemical_Formula
  • C22H28F2O5
Legacy_Concept_Name
  • Diflorasone
CHEBI_ID
  • CHEBI:59750
FULL_SYN
  • DiflorasonePTNCI
  • DIFLORASONEPTFDAT2DHJ9645W
DEFINITION
  • A synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. Like other glucocorticoids, diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorticoid receptor (GR) in the cytoplasm. The receptor complex subsequently translocates to the nucleus and activates or represses genes by interacting with short, palindromic DNA sequences called glucocorticoid response element (GRE). Gene activation leads to the exertion of anti-inflammatory effects, e.g. upregulation of IkappaB, while gene repression inhibits production of pro-inflammatory cytokines such as interleukin-1 (IL-1), IL-2 and IL-6, thereby preventing activation of cytotoxic T-lymphocytes.NCI
code
  • C61722
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