About: Propoxyphene, (+/-)-     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Propoxyphene, (+/-)-
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Propoxyphene, (+/-)-
UMLS_CUI
  • C1880235
CAS_Registry
  • 2621-61-6
FDA_UNII_Code
  • II2G62OV6F
Contributing_Source
  • FDA
Chemical_Formula
  • C22H29NO2
Legacy_Concept_Name
  • DL-Propoxyphene
FULL_SYN
  • DL-PropoxypheneSYNCI
  • Propoxyphene, (+/-)-PTNCI
  • PROPOXYPHENE, (+/-)-PTFDAII2G62OV6F
DEFINITION
  • A racemic mixture of propoxyphene, a synthetic opiate agonist with narcotic analgesic activity. The analgesic effect of propoxyphene is due to its d-isomer, dextropropoxyphene, which bind to opiate receptors, primarily the OP3 receptor located within the central nervous system (CNS). Mediated through G-protein coupled OP3 receptors and cAMP signaling, the release of nociceptive neurotransmitters such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and noradrenaline is inhibited. Propoxyphene also inhibits the release of vasopressin, somatostatin, insulin and glucagon and close N-type voltage-operated calcium channels and open calcium-dependent inwardly rectifying potassium channels. This results in hyperpolarization and reduced neuronal excitability.NCI
code
  • C61711
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