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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Desonide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Desonide
UMLS_CUI
  • C0011705
CAS_Registry
  • 638-94-8
Accepted_Therapeutic_Use_For
  • Dermatitis
FDA_UNII_Code
  • J280872D1O
Contributing_Source
  • FDA
Chemical_Formula
  • C24H32O6
Legacy_Concept_Name
  • Desonide
CHEBI_ID
  • CHEBI:204734
FULL_SYN
  • DESONIDEPTFDAJ280872D1O
  • VerdesoBRNCI
  • DesonidePTNCI
  • DesonateBRNCI
DEFINITION
  • A synthetic glucocorticosteroid for topical use, with anti-inflammatory activity. Desonide binds to glucocorticoid receptors in the cytoplasm, and the ligand-receptor complex is translocated as a homodimer into the nucleus, where transcription activation via glucocorticoid response elements within glucocorticoid-responsive genes occur. This agent induces transcription of genes coding for anti-inflammatory proteins, including lipocortin-1, interleukin-10, interleukin-1 receptor antagonist and neutral endopeptidase. Increased synthesis of lipocortin-1 has an inhibitory effect on phospholipase A2, which in turn inhibits the release arachidonic acid, thereby controlling the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.NCI
code
  • C61702
sameAs
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