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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Desmopressin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Desmopressin
UMLS_CUI
  • C0011701
CAS_Registry
  • 16679-58-6
FDA_UNII_Code
  • ENR1LLB0FP
Contributing_Source
  • FDA
Chemical_Formula
  • C46H64N14O12S2
Legacy_Concept_Name
  • Desmopressin
CHEBI_ID
  • CHEBI:4450
FULL_SYN
  • DESMOPRESSINPTFDAENR1LLB0FP
  • 1-Deamino-8-D-arginine VasopressinSYNCI
  • DesmopressinPTNCI
DEFINITION
  • A synthetic octapeptide, and an analogue of human hormone arginine vasopressin with antidiuretic and coagulant activities. Desmopressin binds to V2 receptors in renal collecting ducts which leads to exocytosis of von Willebrand factor (VWF) and tissue plasminogen activator (t-PA) from Weibel-Palade bodies, thereby increasing water resorption. This agent also increases nitric oxide (NO) production via activation of endothelial NO synthase, thereby induces afferent arteriolar vasodilation. Furthermore, desmopressin stimulates the release of factor VIII from endothelial cells mediated through V1a receptor, thereby promotes blood coagulation.NCI
code
  • C61701
sameAs
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