About: Clodronic Acid     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Clodronic Acid
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Clodronic Acid
UMLS_CUI
  • C0012081
CAS_Registry
  • 10596-23-3
FDA_UNII_Code
  • 0813BZ6866
Contributing_Source
  • FDA
Chemical_Formula
  • CH4Cl2O6P2
Legacy_Concept_Name
  • Clodronic_Acid
CHEBI_ID
  • CHEBI:110423
FULL_SYN
  • CLODRONIC ACIDPTFDA0813BZ6866
  • Clodronic AcidPTNCI
  • (Dichloromethylene)bisphosphonic AcidSNNCI
  • Clodronic AcidPTDCP50682
  • ClodronateSYNCI
DEFINITION
  • A first-generation bisphosphonate with anti-resorptive and anti-hypercalcemic activities. Clodronic acid adsorbs onto the surface of the hydroxyapatite crystals in bone matrix. Although the exact mechanism through which clodronic acid exerts its cytotoxic effect on osteoclasts has yet to be fully elucidated, this agent is metabolized intracellularly to a toxic beta-gamma-methylene analog of adenosine triphosphate (ATP), AppCCl2p. The ATP analog AppCCl2p competitively inhibits ADP/ATP translocase, thereby interfering with mitochondrial membrane potential and cellular energy metabolism. This may cause osteoclast apoptosis and, eventually, inhibiting osteoclast-mediated bone resorption.NCI
code
  • C61685
sameAs
http://linked.open...y/mesh/hasConcept
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