About: Chloroquine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Chloroquine
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Chloroquine
UMLS_CUI
  • C0008269
CAS_Registry
  • 54-05-7
FDA_UNII_Code
  • 886U3H6UFF
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 654729
PDQ_Closed_Trial_Search_ID
  • 654729
Chemical_Formula
  • C18H26ClN3
Legacy_Concept_Name
  • Chloroquine
CHEBI_ID
  • CHEBI:3638
FULL_SYN
  • ChloroquinePTNCI
  • ChloroquinePTDCP00879
  • CHLOROQUINEPTFDA886U3H6UFF
DEFINITION
  • A 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. This agent may also interfere with the biosynthesis of nucleic acids. Chloroquine's potential chemosensitizing and radiosensitizing activities in cancer may be related to its inhibition of autophagy, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species (ROS) related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation.NCI
code
  • C61671
sameAs
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