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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • APF530
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • APF530
UMLS_CUI
  • C1831918
In_Clinical_Trial_For
  • Prevention of chemotherapy-induced acute and delayed nausea and vomiting
PDQ_Open_Trial_Search_ID
  • 494748
PDQ_Closed_Trial_Search_ID
  • 494748
Legacy_Concept_Name
  • APF530
FULL_SYN
  • APF530PTNCI
  • APF-530SYNCI
DEFINITION
  • A controlled-release formulation of a biodegradable poly(ortho ester) polymer, encapsulating the indazole derivative granisetron, with antiemetic activity. Upon administration of APF530, the polymer slowly erodes and releases the active ingredient granisetron. As a selective serotonin receptor antagonist, granisetron competitively blocks the action of serotonin at 5-hydroxytryptamine3 (5-HT3) receptors, resulting in the suppression of nausea and vomiting over a sustained period of time.NCI
code
  • C61567
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