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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Senna Extract
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Senna Extract
UMLS_CUI
  • C0036656
PDQ_Open_Trial_Search_ID
  • 480408
PDQ_Closed_Trial_Search_ID
  • 480408
Legacy_Concept_Name
  • Senna_Extract
FULL_SYN
  • Senna ExtractPTNCI
DEFINITION
  • An extract made from the dried leaflets on the pods of Cassia angustifolia or Cassia acutifolia with cathartic activity. Dimeric glycosides in dried senna extract are converted to the active monoanthrones by bacterial action in the colon. Through direct effects on enterocytes, enteric neurons, and muscle, monoanthrones produce giant migrating colonic contractions in addition to water and electrolyte secretion. As do other stimulant laxatives, monoanthrones may induce a limited low-grade inflammation in the colon through activation of prostaglandin/cyclic AMP and nitric oxide/cyclic GMP pathways and perhaps inhibition of Na+, K+-ATPase.NCI
code
  • C61324
sameAs
http://linked.open...y/mesh/hasConcept
is sameAs of
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