About: pNGVL3-hICD Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • pNGVL3-hICD Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Immunologic Factor
Preferred_Name
  • pNGVL3-hICD Vaccine
UMLS_CUI
  • C1831753
In_Clinical_Trial_For
  • HER-2/neu expressing advanced malignancies.
PDQ_Open_Trial_Search_ID
  • 468837
PDQ_Closed_Trial_Search_ID
  • 468837
Legacy_Concept_Name
  • pNGVL3-hICD_Vaccine
FULL_SYN
  • pNGVL3-hHER2 Intracellular Domain Plasmid DNA VaccineSYNCI
  • pNGVL3-hICD VaccinePTNCI
DEFINITION
  • A plasmid DNA cancer vaccine encoding the intracellular domain (ICD) of the HER-2/neu proto-oncogene. Upon administration and after cellular uptake by skin or muscle cells, the pNGVL3-hICD vaccine plasmid expresses the HER-2/neu protein, which, after intracellular processing, may elicit both antigen-specific cytotoxic T-lymphocyte (CTL) and humoral immune responses against tumor cells expressing HER-2. The HER-2/neu ICD protein is highly immunogenic and, as a subdominant epitope, may be associated with decreased immune tolerance.NCI
code
  • C61146
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