About: Ecromeximab     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Ecromeximab
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
  • Immunologic Factor
Preferred_Name
  • Ecromeximab
UMLS_CUI
  • C1831744
CAS_Registry
  • 292819-64-8
FDA_UNII_Code
  • M76FX2JZRM
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 467926
PDQ_Closed_Trial_Search_ID
  • 467926
Legacy_Concept_Name
  • Monoclonal_Antibody_KW-2871
FULL_SYN
  • EcromeximabPTNCI
  • KM871CNNCI
  • KW-2871CNNCI
  • Immunoglobulin G1, Anti-(Gd3 Ganglioside) (Human-Mouse Monoclonal Km871 .Gamma.1-Chain), Disulfide with Human-Mouse Monoclonal KM871 .Kappa.-Chain, DimerSYNCI
  • Chimeric Monoclonal Antibody KW-2871SYNCI
  • Monoclonal Antibody KW-2871SYNCI
  • ECROMEXIMABPTFDAM76FX2JZRM
DEFINITION
  • A low-fucose, human-mouse chimeric IgG1 monoclonal antibody with potential antineoplastic activity targeting at the ganglioside GD3, a surface antigen expressed on many malignant melanoma cells. Monoclonal antibody KW-2871 binds to GD3-positive cells, thereby initiating antibody-dependent cytotoxicity against GD3-positive cells. This agent is prepared by fusing murine immunoglobulin (Ig) light and heavy variable regions derived from the murine IgG3 antibody KM-641 to a human constant (Fc) region. The low fucose content of the oligosaccharide side chains of this antibody may enhance binding of the antibody Fc region to lymphocyte Fc receptors.NCI
code
  • C61095
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