About: MAGE-A3/HPV 16 Peptide Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • MAGE-A3/HPV 16 Peptide Vaccine
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • MAGE-A3/HPV 16 Peptide Vaccine
UMLS_CUI
  • C1831802
PDQ_Open_Trial_Search_ID
  • 478746
PDQ_Closed_Trial_Search_ID
  • 478746
Legacy_Concept_Name
  • MAGE-A3_HPV-16_Peptide_Vaccine
FULL_SYN
  • MAGE-A3/HPV 16 Peptide VaccinePTNCI
DEFINITION
  • A multi-epitope Trojan antigen (TA) construct vaccine consisting of human melanoma antigen A3 (MAGE-A3) and human papillomavirus (HPV) 16 peptide epitopes linked by the furin-sensitive linker peptide RVKR (arginine-serine-lysine-arginine) with immunostimulatory and antitumor activities. The TA construct enters the cytoplasm of antigen-presenting cells (APC) and is processed by the endoplasmic reticulum (ER) and the trans-Golgi network (TGN), where the endopeptidase furin releases the epitopes from the RVKR linker peptide and, together with various exopeptidases, generates MHC class I-binding peptides. Expressed on the cell surfaces of APC, these MHC class I-binding peptides stimulate a cytotoxic T lymphocyte (CTL) response against tumor cells that display the same peptide epitopes on their cell surfaces.NCI
code
  • C61088
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