About: Sodium Stibogluconate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Sodium Stibogluconate
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
  • Chemical Viewed Functionally
Preferred_Name
  • Sodium Stibogluconate
UMLS_CUI
  • C0003383
CAS_Registry
  • 12001-86-4
  • 16037-91-5
FDA_UNII_Code
  • V083S0159D
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of certain solid tumors, lymphoma, and myeloma. Sodium stibogluconate may block enzymes needed for cancer growth. It is a type of pentavalent antimonial.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 475763
PDQ_Closed_Trial_Search_ID
  • 475763
Chemical_Formula
  • C12H18O17Sb2.2Na
Legacy_Concept_Name
  • Sodium_Stibogluconate
CHEBI_ID
  • CHEBI:28148
FULL_SYN
  • SSGPTNCI-GLOSSCDR0000523297
  • SODIUM STIBOGLUCONATEPTFDAV083S0159D
  • SolustibosanFBNCI
  • Antimony Sodium GluconateSYNCI
  • SSGABNCI
  • VQD001CNNCI
  • sodium stibogluconatePTNCI-GLOSSCDR0000482341
  • Sodium StibogluconatePTDCP50554
  • LenoctaBRNCI
  • SolustinFBNCI
  • PentostamFBNCI
  • MyostibinFBNCI
  • Sodium StibogluconatePTNCI
DEFINITION
  • Pentavalent antimony (Sb) in differential complex formation with gluconic acid with leishmanicidal and potential antineoplastic activities. The Sb moiety of sodium stibogluconate (SSG) may inhibit protein tyrosine phosphorylases (PTPases) by covalently modifying sulfhydryl groups in PTPase cysteine residues, resulting in specific inactivation of SH2 domain-containing tyrosine phosphatases-1 and -2 (SHP-1 and SHP-2), PTPases which negatively regulate interferon (IFN) signaling; enhancement of IFN-induced Stat1 tyrosine phosphorylation; and induction of cellular protein tyrosine phosphorylation. SSG in combination with IFN-alpha may synergize to overcome tumor cell resistance to IFN-alpha-mediated apoptosis.NCI
code
  • C61083
sameAs
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