About: Synthetic Breast Cancer Peptides-Tetanus Toxoid-Montanide ISA-51 Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Synthetic Breast Cancer Peptides-Tetanus Toxoid-Montanide ISA-51 Vaccine
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Synthetic Breast Cancer Peptides-Tetanus Toxoid-Montanide ISA-51 Vaccine
UMLS_CUI
  • C1831781
PDQ_Open_Trial_Search_ID
  • 474021
PDQ_Closed_Trial_Search_ID
  • 474021
Legacy_Concept_Name
  • Synthetic_Breast-Cancer-Peptides_Tetanus-Toxoid_Montanide-ISA-51_Vaccine
FULL_SYN
  • Synthetic Breast Cancer Peptides-Tetanus Toxoid-Montanide ISA-51 VaccinePTNCI
DEFINITION
  • A cancer vaccine comprised of multiple synthetic breast cancer peptides and the adjuvant tetanus toxoid helper peptide emulsified in the adjuvant Montanide ISA-51 with immunopotentiation activity. Vaccination with this cancer vaccine may elicit a specific cytotoxic T-lymphocyte response against breast cancer cells. Synthetic breast cancer peptides may stimulate the immune response against cells that produce breast cancer markers such as erbB2 (HER2/neu) while tetanus toxoid helper peptide binds to class II MHC molecules as a nonspecific vaccine helper epitope, resulting in a long-term immunopotentiation by increasing the helper T-cell response. Montanide ISA-51, also known as incomplete Freund's adjuvant or IFA, is a stabilized water-in-oil emulsion adjuvant containing mineral oil with mannide oleate added as a surfactant that non-specifically stimulates cell-mediated immune responses to antigens.NCI
code
  • C61076
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