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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Sagopilone
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Chemical Viewed Structurally
Preferred_Name
  • Sagopilone
UMLS_CUI
  • C2355512
CAS_Registry
  • 305841-29-6
FDA_UNII_Code
  • KY72JU32FO
Contributing_Source
  • FDA
ALT_DEFINITION
  • A form of the substance epothilone that is made in the laboratory. It is being studied in the treatment of some types of cancer. Epothilone ZK2219477 stops the growth of tumor cells by blocking cell division. It is a type of antimitotic agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 615854
PDQ_Closed_Trial_Search_ID
  • 615854
Chemical_Formula
  • C30H41NO6S
Legacy_Concept_Name
  • ZK219477
FULL_SYN
  • SagopilonePTNCI
  • epothilone ZK219477PTNCI-GLOSSCDR0000537170
  • ZK-EpothiloneSYNCI
  • (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,12,16-tetramethyl-3-(2-methyl-1,3-benzothiazol-5-yl)-10-(prop-2-enyl)-4,17-dioxabicyclo(14.1.0)heptadecane-5,9-dioneSNNCI
  • ZK-EPOABNCI
  • Epothilone ZK219477SYNCI
  • DE-03757CNNCI
  • SAGOPILONEPTFDAKY72JU32FO
  • ZK-219477CNNCI
  • SH-Y03757ACNNCI
DEFINITION
  • A fully synthetic low-molecular-weight epothilone with potential antineoplastic activity. Sagopilone binds to tubulin and induces microtubule polymerization while stabilizing microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. The agent is not a substrate for the P-glycoprotein (P-gp) efflux pump and so may exhibit activity in multidrug-resistant (MDR) tumors. The epothilone class of metabolites was originally isolated from the myxobacterium Solangium cellulosum.NCI
code
  • C61072
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