About: Recombinant Bispecific Single-Chain Antibody rM28     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Recombinant Bispecific Single-Chain Antibody rM28
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • Recombinant Bispecific Single-Chain Antibody rM28
UMLS_CUI
  • C1831730
In_Clinical_Trial_For
  • Malignant Melanoma
PDQ_Open_Trial_Search_ID
  • 467183
PDQ_Closed_Trial_Search_ID
  • 467183
Legacy_Concept_Name
  • Recombinant_Bispecific_Single-Chain_Antibody_rM28
FULL_SYN
  • rM28CNNCI
  • Recombinant Bispecific Single-Chain Antibody rM28PTNCI
DEFINITION
  • A recombinant, bispecific, single-chain antibody directed against both the T-cell surface-associated costimulatory molecule CD28 and a melanoma-associated proteoglycan (MAPG) with potential antitumor activity. By targeting both CD28 and MAPG, recombinant bispecific single-chain antibody rM28 enhances cytotoxic T-cell recognition of melanoma cells, which may result in immune effector cell-mediated tumor cell death and a decrease in distant metastases. This agent appears to have a long serum half-life secondary to the formation of dimers. When activated, CD28 facilitates interactions between T-cells and other immune effector cells resulting in cytotoxic T-lymphocyte responses; MAPG is a surface antigen expressed on the majority of melanomas, including primary cutaneous, ocular, and metastatic melanomas.NCI
code
  • C60882
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