About: Hypertonic Saline     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Hypertonic Saline
rdfs:subClassOf
Semantic_Type
  • Inorganic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Hypertonic Saline
UMLS_CUI
  • C0036085
PDQ_Open_Trial_Search_ID
  • 467928
PDQ_Closed_Trial_Search_ID
  • 467928
Legacy_Concept_Name
  • Hypertonic_Saline
FULL_SYN
  • Hypertonic Saline SolutionSYNCI
  • Hypertonic SalinePTNCI
DEFINITION
  • Any solution of sodium chloride (NaCl) in water with a concentration of NaCl higher than that found in physiological saline (0.9% w/v). When administered in vivo, hypertonic saline (HTS) exhibits several physiological effects beneficial to cerebral injury including: 1) osmotic and vasoregulatory - by promoting the flow of excess water from cerebral tissue to the blood via osmosis and decreasing edema in the vascular endothelium of injured tissues, thus lowering vascular resistance and allowing more blood flow; 2) hemodynamic - by effectively expanding plasma volume; 3) immunomodulatory - by preventing leukocytes from becoming activated and adhering to injured neurons and; 4) neurochemical - by counteracting detrimental excitatory amino acids through the normalization of neuronal cell membranes and by restoration of normal electrolyte and neurotransmitter levels in brain cells, and normal cell volumes.NCI
code
  • C60814
http://linked.open...y/mesh/hasConcept
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