About: SDZ 280-446     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • SDZ 280-446
rdfs:subClassOf
Has_Target
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • SDZ 280-446
UMLS_CUI
  • C0141820
CAS_Registry
  • 129893-84-1
Legacy_Concept_Name
  • SDZ_280-446
FULL_SYN
  • Cyclo-(pec1-meval2-val3-(O-t-Bu-measp4)-melle5-melle6-gly7-meval8-(O-Me-tyr)-L-hpa10)SNNCI
  • SDZ 280-446PTNCI
DEFINITION
  • A novel semi-synthetic derivative of cyclosporin and a cyclodepsipeptide with chemo-sensitizing activity. SDZ 280-446 is one of the drug resistance-modifying agents that inhibit P-glycoprotein, the multidrug resistance efflux pump, thereby restoring the retention and activities of some drugs in drug-resistant tumor cells.NCI
code
  • C60767
http://linked.open...y/mesh/hasConcept
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