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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Isoniazid
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Isoniazid
NSC_Code
  • 9659
UMLS_CUI
  • C0022209
CAS_Registry
  • 54-85-3
FDA_UNII_Code
  • V83O1VOZ8L
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 39484
PDQ_Closed_Trial_Search_ID
  • 39484
Chemical_Formula
  • C6H7N3O
Legacy_Concept_Name
  • Isoniazid
CHEBI_ID
  • CHEBI:6030
FULL_SYN
  • Isonicotinyl HydrazineSNNCI
  • Isonicotinic Acid HydrazideSNNCI
  • ISONIAZIDPTFDAV83O1VOZ8L
  • IsoniazidSYDTPNSC0009659
  • IsoniazidPTNCI
DEFINITION
  • A synthetic derivative of nicotinic acid with anti-mycobacterial properties. Although its mechanism of action is still unclear, isoniazid appears to block the synthesis of mycolic acids, major components of the mycobacterial cell wall. This agent is only active against actively growing mycobacteria because, as a pro-drug, it requires activation in susceptible mycobacterial species. Isoniazid also interferes with mycobacterial metabolism of vitamin B6. Resistance occurs due to decreased bacterial wall penetration. (NCI04)NCI
code
  • C600
sameAs
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